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Influence of Menopause on the Risk of Cardiovascular Disease and Bone Loss in the Postmenopausal Women
Author(s) -
Malepati Dhananjaya Naidu,
Goudu Sivanarayana,
G Jagadesh
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.547.14
Subject(s) - medicine , menopause , osteoporosis , endocrinology , risk factor , bone resorption , surgical menopause , hormone replacement therapy (female to male) , physiology , testosterone (patch)
Menopause is considered to be a cardiovascular risk factor and exogenous hormone therapy after menopause was demonstrated to contribute to heart health. In the present study, the effect of menopause on cardiovascular disease (CVD) and bone resorption has been investigated. The incidence of coronary heart disease and the risk of osteoporosis increase sharply after menopause in women. We compared 96 postmenopausal women (study group) and 40 premenopausal women (control group). Their postmenopausal status was confirmed by serum estradiol levels. Compared to premenopausal women, postmenopausal women had significantly increased the levels of total cholesterol (TC) (P<0.001), atherogenic index (TC/high density lipoprotein) (P<0.001), urine C‐telopeptides of type I collagen (CTX‐I) (P<0.001) and serum tartrate resistant Acid Phosphatase‐5 b (TRACP‐5B) (P < 0.001). These results suggest that the menopausal status may have a significant effect on the primary cardiovascular risk factors such as total cholesterol, atherogenic index and the risk of osteoporosis (TRACP‐5B, CTX‐I) in the postmenopausasl women. This study suggests that the Physicians should consider both the risk of CVD and bone loss while initiating the therapies.