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Benzoate Esters as Potential Apoptotic Agents
Author(s) -
Sharma Bharat,
Ellis Jamie,
Foroozesh Maryam,
Hopkins Nancy Eddy
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.534.3
Subject(s) - prostate cancer , curcumin , apoptosis , cancer , cancer cell , chemistry , stereochemistry , prostate , cancer research , biochemistry , pharmacology , combinatorial chemistry , biology , medicine
Many natural products such as curcumin, capsaicin, and isoflavonoids are thought to have chemo‐preventative properties for cancer, especially prostate cancer. 4‐Hydroxy‐3‐methoxybenzoic acid methyl ester (methyl vanillate) has been shown to cause proliferation inhibition in the human and mouse prostate cancer cells. In this project, we have synthesized a series of related aromatic compounds containing an ester functional group and one or more hydroxyl or methoxy ring substituents. The newly synthesized benzoate esters are studied in cell culture studies with human and mouse prostate cancer cells. Due to their structural similarities to compounds known to cause prostate cancer cell apoptosis, these compounds are expected to provide us with new and valuable information about the structural requirements for optimizing that effect. Considering that prostate cancer is the second most common type of cancer in men in the United States (second only to skin cancer), these and related studies are of great importance in the fight against cancer. Here we will present the synthesis, purification, structural analysis and the preliminary assay data obtained for a number of these compounds.