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Chasing nanodiamond in cell cycle progression
Author(s) -
Chao JuiI,
Liu KuangKai
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.534.2
Subject(s) - nanodiamond , cell cycle progression , cell cycle , cell , cytosol , microbiology and biotechnology , chemistry , cell growth , nucleus , biophysics , nanoparticle , a549 cell , nanotechnology , materials science , biology , biochemistry , organic chemistry , diamond , enzyme
Nanodiamond (ND) is a promising nanomaterial for biomedical applications. After treatment with 100 nm ND particles, these cells were re‐cultured in fresh medium for long‐term observation, which counted the total cell number of every 2 day in A549 and 3T3‐L1 cells. ND particles did not inhibit the cell growth ability after cultured 10 days. Furthermore, the cell cycle progression of these cells did not alter by ND particles. Interestingly, the ND¡ ?s particles were retained in the inside of cells. It was formed a single ND¡¦ s cluster in cytosol but not nucleus. ND particles can be persistently existed in cell but without inducing cell damage. Our findings provide ND particles that are compatible in cell cycle progression.