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Preliminary investigation to the synthesis of gamma amino acids
Author(s) -
McCormick Casey Jerome,
Swartling Daniel J
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.534.1
Subject(s) - knoevenagel condensation , nitromethane , yield (engineering) , chemistry , adduct , amino acid , organic chemistry , condensation , michael reaction , stereochemistry , biochemistry , catalysis , materials science , physics , metallurgy , thermodynamics
Cyclic and acyclic precursors are being prepared for conversion in several steps to gamma amino acid analogs, which may possess biological activity. Cyclic and acyclic aldehydes and ketones were coupled to Meldrum's acid using the Knoevenagel condensation method to yield the corresponding adducts. These will be reacted with nitromethane to form the corresponding Michael addition products, which will be reduced and decarboxylated to form gamma amino acid analogs.