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Endothelins derived from vascular endothelial cells promote cortical neurite elongation
Author(s) -
MURAMATSU RIEKO,
UESUGI NORIKO,
YAMASHITA TOSHIHIDE
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.524.5
Subject(s) - neurite , endothelins , microbiology and biotechnology , endothelin receptor , neuroscience , biology , regeneration (biology) , endothelin 1 , receptor , in vitro , biochemistry
Branched structure of blood vessels and nerves are similar in adult tissue, suggesting that one may regulate the other patterning during ontogenesis. Given that this regulation continues to work during adulthood, enhancement of this mechanism may contribute to regeneration of injured neural network. To elucidate the crosstalk of vascular system and neurons, we employed co‐culture of cortical neurons and cortical capillary endothelial cells, and found that diffusible factors derived from capillary endothelial cells elongated cortical neurites in vitro. As endothelin receptors were expressed in cortical neurons, we next investigated the effects of endothelins, as factors secreted from capillary, on the nerite length. Treatment with each endothelin isoform promoted cortical neurite extension. These results suggest that endothelins derived from vascular endothelial cells could promote neurite elongation and may contribute to regeneration of the injured CNS.