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Control of breast cancer by dietary alpha‐lactalbumin is mediated by regulation of retinoid metabolism and signaling
Author(s) -
Sinha Roy Somdutta,
Schäffer Michael W,
Mukherjee Shyamali,
Das Salil K
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.524.18
Subject(s) - retinoid , breast cancer , casein , endocrinology , medicine , retinoic acid , retinyl palmitate , alpha lactalbumin , lactalbumin , alpha (finance) , chemistry , dmba , receptor , retinol , cancer , cancer research , biochemistry , vitamin , carcinogenesis , gene , construct validity , nursing , patient satisfaction
Dietary protein is a significant factor in breast cancer control. However, no information is available concerning the effects of á‐lactalbumin on the expression of certain genes involved in breast cancer control. Breast cancer was developed by gavage administration of DMBA in female rats, maintained on AIN‐76A diet with either casein or á‐lactalbumin as protein source for 120 days. The whey group had less cancer than the casein group. Casein group had a mixture of grade I, grade II and grade III tumors whereas the whey group had mostly grade I tumor. The levels of retinoic acid (RA), retinol (ROH) and retinyl palmitate (RP) were 44, 430, 606 µg/g, respectively in control tissue, and their levels were significantly reduced in tumors. However, the decrease of RA, ROH and RP was significantly less in the whey group (77, 48, 45%, respectively) than that in the casein group (84.5%, 69.5% and 54.6%, respectively). The expression of various binding proteins and mediators of retinoid action like, CRBP I, CRABP II, LRAT and nuclear RAR and RXR receptors also show similar variation among these groups. (Supported by FAMRI Clinical Innovator Award # 62415)