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VEGF Regulates Cervical Remodeling By Increasing Epithelial Folds During Pregnancy in Rodents
Author(s) -
Palmer Jennifer,
Scott Kelsey,
Mowa Chishimba Nathan
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.473.3
Subject(s) - vegf receptors , cervix , pregnancy , epithelium , ovariectomized rat , biology , andrology , endocrinology , medicine , pathology , estrogen , cancer , genetics
Cervical remodeling is a physiological inflammatory process which is associated and possibly regulated by proliferating cervical epithelial. We have previously shown that levels of VEGF increase with advancing pregnancy in rodents (mice and rats). Here, we show that as VEGF increases, the folds in the surface epithelium of the cervix increase as pregnancy advances in untreated rodents, which we interpreted as increased epithelial growth. We also show that ovariectomized nonpregnant rodents treated with VEGF have increased epithelial folds versus control using SEM.. We conclude that VEGF plays a role in cervical remodeling as pregnancy progresses by an increase in epithelial proliferation.