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Mining the receptorome: an efficient approach for target discovery and validation
Author(s) -
Roth Bryan L
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.424.1
Subject(s) - drug discovery , computational biology , massively parallel , drug , computer science , chemistry , data science , pharmacology , bioinformatics , biology , parallel computing
In this talk I will demonstrate the power of screening drugs and drug‐like compounds in a massively parallel fashion against the GPCR‐ome‐‐the most abundant family in the receptorome (see Armbruster and Roth, JBC 2005 for review). In this talk I will show how this procedure is highly suited to discovering the molecular target(s) responsible for drug actions and side‐effects in vivo.