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Aging and Vascular Progenitor Cells
Author(s) -
DeSouza Christopher
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.420.2
Subject(s) - progenitor cell , medicine , neovascularization , endothelial dysfunction , endothelial progenitor cell , angiogenesis , stem cell , cancer research , microbiology and biotechnology , biology
Endothelial injury without a sufficient compensatory reparative response is thought to accelerate the progression of cardiovascular disease and its clinical consequences including death. Circulating vascular progenitor cells, particularly endothelial progenitor cells (EPCs), are recognized to play a critically important role in maintaining, repairing and/or regenerating the endothelial monolayer and restoring functional activity. The continuous circulation of EPCs is considered to be an important haemostatic mechanism of counteracting ongoing vascular injury in order to preserve organ viability. In addition to reendothelilaization, EPCs also contribute significantly to post natal neovascularization. EPC dysregulation has been linked to a number of pathologies associated with increased cardiovascular risk, including aging. This platform session will outline the adverse influence of advancing age on EPC functional characteristics and their association with age‐related endothelial dysfunction.