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Morphological changes, gene expression and prognosis in papillary thyroid carcinoma
Author(s) -
Bai Yanhua,
Nakamura Misa,
Li Yaqiong,
Liu Zhiyan,
Ozaki Takashi,
Mori Ichiro,
Yashihiro Ito,
Miyauchi Akira,
Kakudo Kennichi
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.38.10
Subject(s) - psammoma body , stromal cell , periostin , thyroid carcinoma , pathology , calcification , stroma , medicine , cancer research , thyroid , biology , endocrinology , immunohistochemistry , extracellular matrix , microbiology and biotechnology
Loss of cellular polarity/cohesiveness (LPC) and periostin expression are involved in the epithelial‐mesenchymal transition in the epithelial malignancies. Their roles in papillary thyroid carcinoma (PTC) were studied. There was a significant correlation between LPC in the invasive front and the up‐regulation of periostin in the tumors. Both of them were significantly correlated with extrathyroid invasion (ex) and pT. In addition, LPC in the invasive front was correlated with a significant poor disease‐free survival(DFS) in 181 cases of PTC. The presence of psammoma body was correlated with a significant poor DFS, but not stromal calcification and bone formation. The up‐regulation of BMP‐1 was in association with psammoma body.