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Indices of insulin sensitivity and secretion from a standard liquid meal test in subjects with type 2 diabetes, impaired and normal fasting glucose
Author(s) -
Maki Kevin C.,
McKenney James M.,
Farmer Mildred V.,
Reeves Matthew S.,
Dicklin Mary R.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.351.1
Subject(s) - medicine , endocrinology , insulin , insulin resistance , diabetes mellitus , area under the curve , impaired fasting glucose , type 2 diabetes , meal , glucose tolerance test , impaired glucose tolerance
This study examined insulin sensitivity and secretion indices from a standard liquid meal tolerance test protocol in subjects with normal (NFG, n = 19), impaired fasting glucose (IFG, n = 19) and type 2 diabetes mellitus (n = 35). Areas under the curve (AUC) for glucose and insulin from pre‐meal to 120 min after a liquid meal were calculated, as were homeostasis model assessments of insulin resistance (HOMA2‐IR) and the Matsuda index of insulin sensitivity. Subjects with NFG, IFG and diabetes had mean fasting glucose levels of 5.22, 5.87 and 7.53 mmol/L and insulin of 52.8, 82.0 and 124.8 pmol/L, respectively. Subjects with NFG, IFG and diabetes had mean HOMA2‐IR values of 1.00, 1.57 and 2.48; glucose AUC of 11.1, 14.1 and 23.1 h*mmol/L; insulin AUC of 894, 1346 and 922 h*pmol/L; insulin/glucose AUC ratio of 78.6, 95.5 and 40.7 pmol/mmol; and Matsuda Index values of 15.6, 8.8 and 6.0, respectively. The product of the insulin/glucose AUC ratio and the Matsuda index, calculated as an indicator of the ability of insulin secretion to match the level of insulin resistance, was 995.6, 684.0, 188.3 for NFG, IFG and diabetes, and discriminated between fasting glucose categories (p < 0.001 for each comparison). These results provide initial evidence of the usefulness of a standard liquid meal tolerance test for evaluation of insulin secretion and sensitivity in clinical and population studies. Funded by Cargill Corporation (Wayzata, MN).