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Composite Phenotypes of Interrelated Lipoprotein Subclasses Independently Predict Diet‐Induced Changes in Plasma Lipids and Lipoproteins
Author(s) -
Chiu Sally,
Krauss Ronald M
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.350.7
Subject(s) - medicine , lipoprotein , apolipoprotein b , endocrinology , very low density lipoprotein , cholesterol , triglyceride , chemistry , phenotype , biology , biochemistry , gene
There is considerable interindividual variation in lipid and lipoprotein responses to diets aimed at reducing risk for cardiovascular disease. We used unsupervised principal component (PC) analysis to test whether composite measures of plasma levels of individual VLDL, LDL, and HDL subfraction mass as measured by analytical ultracentrifugation identified phenotypes that predicted changes in plasma lipids and lipoproteins in response to low‐fat, high‐carbohydrate diets in 548 healthy non‐obese men. Three PCs accounted for 72% of the overall variance in lipoprotein fractions at baseline (high fat). The largest (PC1, 42%), represented a combination of increased small LDL and reduced large LDL. PC1 was significantly (p<0.0001) associated with % reductions in triglyceride, LDL cholesterol (C), and apoB, and increases in HDLC. PC2 (19%), which represented increased mass of small HDL, IDL, and medium and large LDL, was associated (p<0.001) with % reductions in both LDLC and HDLC. PC3 (11%) consisted of increased small and large HDL, together with reduced medium LDL, and was associated (p<0.0001) with % HDLC reduction. The lipoprotein subfraction phenotypes identified by PC analysis may represent the effects of distinct metabolic pathways that contribute independently to variation in response to dietary interventions for improving plasma lipid profiles. (support: National Dairy Council).