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The effect of a weight reducing low carbohydrate vegan diet on apolipoproteins and blood pressure
Author(s) -
Wong Julia M W,
Kendall Cyril W C,
Esfahani Amin,
Ng Vivian W Y,
Greaves Kathryn A,
Paul Greg,
Jenkins David J A
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.345.1
Subject(s) - vegan diet , apolipoprotein b , blood pressure , weight loss , carbohydrate , medicine , endocrinology , blood lipids , cholesterol , food science , body weight , zoology , chemistry , obesity , biology
Objective To determine the effect of a weight reducing low carbohydrate vegan diet, high in soy protein and vegetable oil, on apolipoproteins (apo) and blood pressure (BP) under metabolic conditions. Method Forty‐seven hypercholesterolemic subjects (19M, 28F; 56.9±7.5y; 30.9±2.7kg/m2) were instructed to take a low carbohydrate (26%) high protein vegan diet (test) or a low saturated fat National Cholesterol Education Program ATP III diet (control). For one month, with all food provided, subjects consumed 60% of their estimated energy requirements. Results Forty‐four subjects completed the study. Body weight fell equally by 3.5% on both diets. LDL‐C was reduced more on the test than the control diet (‐20.4±2.8% vs. ‐12.3±2.6%, P=0.002). The corresponding values for apoB and the apoB:apoA‐1 ratio were ‐21.1±2.8% vs. ‐13.2±2.2% (P=0.001) and ‐13.8±3.4% vs. ‐4.2±2.1% (P=0.001). Blood pressure was also reduced on the test than the control diet (systolic BP: ‐4.6±1.0% vs. ‐2.7±1.2%, P=0.046; diastolic BP: ‐5.8±1.0% vs. ‐3.1±1.4, P=0.014). Conclusion Weight loss reduces apoB, the apoB:apoA‐1 ratio and blood pressure more on a low carbohydrate vegan diet, high in vegetable protein and oil, than on a standard therapeutic diet. Funding: The Solae Company, Loblaw Companies Limited Grant Funding Source Canadian Institutes of Health Research