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Milk consumption and cholesterol homeostasis in postmenopausal women with abdominal obesity
Author(s) -
Lamarche Benoit,
Labonté MarieEve,
Gag Josée,
Desroches Sophie,
Charest Amélie,
Lemieux Simone,
Couture Patrick
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.343.8
Subject(s) - abdominal obesity , cholesterol , medicine , endocrinology , lathosterol , obesity , food science , chemistry , metabolic syndrome , sterol , campesterol
The objective of this study was to investigate using a randomized, cross over study design the impact of milk consumption on markers of cholesterol absorption and synthesis in postmenopausal women with abdominal obesity. Twenty‐seven women with abdominal obesity consumed under controlled conditions a diet rich in milk (MILK) and a control diet designed according to the National Cholesterol Education Program (NCEP) dietary recommendations, in a random order for 6 weeks each. The macronutritional composition of both diets was comparable (55% carbohydrates, 15% proteins, 30% fat and 10% saturated fat). Milk accounted for 20% of energy intake in the MILK diet. Neither the MILK nor the NCEP diet had an impact on plasma cholesterol, triacylglycerol and apolipoprotein (apo) B concentrations. However, the plasma concentration of β‐sitosterol, a surrogate of intestinal cholesterol absorption, was reduced after the MILK diet compared with NCEP control diet (‐9.2%, P=0.07). The β‐sitosterol/lathosterol ratio, a marker of cholesterol homeostasis that shows a strong correlation with abdominal obesity, was also reduced significantly after the MILK diet compared with the NCEP diet (‐14.9%, P=0.01). These data suggest that while milk consumption may have little effect on plasma cholesterol concentration, it may be associated with subtle but significant changes in cholesterol homeostasis in women with abdominal obesity.