Premium
Small molecule and genomic approaches to bacterial pathogenesis
Author(s) -
Hung Deborah T.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.328.1
Subject(s) - biology , computational biology , genome , mycobacterium tuberculosis , tuberculosis , pathogenic bacteria , identification (biology) , infectious disease (medical specialty) , genomics , small molecule , bacteria , disease , genetics , gene , medicine , botany , pathology
Infectious diseases account for almost 1/3 of total deaths worldwide. A better understanding of how bacterial pathogens cause disease will lead to new paradigms for treatment and management of such diseases. Small molecules can be valuable tools to dissect the pathogenic interactions between the host and bacteria, both in vitro and in vivo. In addition, the smaller genomes of bacteria allow comprehensive genomic approaches to be developed and utilized to identify the targets of active small molecules, to understand the mechanisms of these small molecule probes and to elucidate the fundamental biology of infection. We will illustrate several examples of genomic approaches to target identification in the study of Mycobacterium tuberculosis.