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Tales of Transposons: Mechanisms and Applications
Author(s) -
Craig Nancy Lynn,
Mitra Rupak,
Xie Kefang
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.315.2
Subject(s) - mobile genetic elements , transposable element , transposition (logic) , genome , myotis lucifugus , biology , dna , retrotransposon , genetics , computational biology , gene , computer science , zoology , artificial intelligence
Mobile elements are ubiquitous genome components sequences derived from mobile elements can make up large fractions of genomes. Our research is focused on DNA‐only elements that move by excision from the donor site, followed by insertion into the target site. We have dissected the transposition mechanisms of the hAT and piggyBac superfamiles of elements. We have also isolated hyperactive elements to probe their transposition mechanism and to use as tools for genome engineering. Heretofore, no active DNA‐only element has been isolated from a mammal. We have now isolated an active DNA‐only element from the little brown bat Myotis lucifugus.