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Clinical correlations to limbic structure and function
Author(s) -
Rao Jayaraman
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.301.3
Subject(s) - limbic system , neuroscience , limbic lobe , amygdala , psychology , orbitofrontal cortex , frontal lobe , prefrontal cortex , anxiety , temporal lobe , mood disorders , anterior cingulate cortex , psychiatry , cognition , central nervous system , epilepsy
Since the original description of the "le grand lobe limbic" by Paul Broca in 1878, several areas of the frontal, temporal, and amygdala regions have been added on to be part of the "limbic lobe". While the debate about what constitutes the limbic lobe is continuing, dysfunctions of several regions of the limbic lobe have been implicated to cause many neuropsychiatric disorders. Recent experimental evidence strongly suggest that the orbitofrontal cortex, dorsolateral and medial prefrontal cortex and subgenual anterior cingulate gyrus may be involved in obsessive compulsive disorder, anxiety disorders, drug dependence, suicidal depression, bipolar and mood disorders. The discussion will expand on the experimental and clinical evidence supporting these evolving concepts. The potential target sites to improve the clinical syndrome of obsessive compulsive behavior and depression with deep brain stimulation technique will be elaborated.