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Carbohydrate‐related dietary factors and plasma adiponectin levels in healthy adults in the Framingham Offspring Cohort.
Author(s) -
McKeown Nicola Mary,
Liu Enju,
Meigs James B,
Rogers Gail,
D'Agostino Ralph,
Jacques Paul
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.229.5
Subject(s) - adiponectin , medicine , glycemic index , endocrinology , glycemic load , glycemic , insulin , offspring , cohort , insulin resistance , pregnancy , biology , genetics
Diet may influence circulating adiponectin levels by improving insulin sensitivity. We examined the associations between carbohydrate‐related dietary factors and plasma adiponectin levels in healthy adults aged 26‐81 y (n= 979 men and 1227 women). Dietary intakes were assessed using a FFQ. Fasting plasma adiponectin was assayed with an immunoassay kit. After adjustment for age, sex, BMI, total energy intake, current smoking status, % energy from fat and alcohol consumption, higher intakes of dietary fiber were positively associated with plasma adiponectin (10 % difference between highest (Q5) and lowest (Q1) quintile; p trend= 0.04), while dietary glycemic index (DGI) inversely associated with plasma adiponectin (10% difference between Q5 and Q1; p trend <0.001). A marginally significant positive association was observed between cereal fiber and whole‐grain intakes and plasma adiponectin levels ( p trend =0.06). However, only the association between DGI and plasma adiponectin levels remained significant after adjustment for fasting insulin. Total carbohydrate, fruit, vegetable, legume/nut fibers, glycemic load, and refined grain intakes were not associated with adiponectin levels. In conclusion, a high DGI may influence adiponectin by mechanisms independent of insulin. Supported in part by funding from General Mills Bell Institute of Research, the USDA Agreement 58‐1950‐7‐707 and the Framingham Heart Study of the National Heart Lung and Blood Institute of the NIH (Contract N01‐HC‐25195)