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Maternal exposure to diets containing high fructose and saturated fats, low B vitamins, or their combination programs growth, adiposity, and insulin sensitivity in adult offspring
Author(s) -
Chen ChungYen Oliver,
Crott Jimmy,
Liu Zhenhua,
Smith Donald
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.219.6
Subject(s) - offspring , weaning , endocrinology , medicine , biology , insulin , gestation , pregnancy , zoology , genetics
Early exposure to unfavorable nutrition programs risk of adult‐onset diseases. In this rat study, we investigate morphological, metabolic and endocrinal phenotypes of offspring born to dams consuming isocaloric diets containing 30% fructose, 9.9% coconut fat and 0.5% cholesterol (F+SFA), mild deficiencies of four B vitamins (VBD), or their combination (F+SFA+VBD) for 4 wk before conception and during gestation and nursing. After weaning, all offspring were rehabilitated with the control diet (C) containing 30% glucose, 11% corn oil, and optimal vitamins for 12 wk. The VBD and F+SFA+VBD diets caused intrauterine growth retardation. The VBD offspring underwent a period of catch‐up growth and had the largest body weight (BW) at age of 15 wk. However, the F+SFA+VBD male adult offspring were stunted. The F+SFA and F+SFA+VBD led to at least 44% smaller BW‐adjusted retroperitoneal fat depots in male offspring. Further, the F+SFA male offspring had 64% larger fasted plasma insulin and the VBD male offspring had 2.6‐fold larger plasma testosterone than the C. Our results illustrate that nutrition in early life may have great impacts on growth trajectory, adiposity, and hormonal status in adulthood in a sex dependent manner. However, mechanistic mechanisms underlying this nutrient programming remain to be investigated. The study was sponsored by the USDA ARS under Cooperative Agreement.