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Relationship between Endogenous Fecal Zinc and Zinc Absorbed Revisited
Author(s) -
Hambidge K Michael,
Miller Leland V,
Krebs Nancy F
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.216.8
Subject(s) - zinc , endogeny , linear regression , chemistry , excretion , feces , zoology , significant difference , statistics , mathematics , biology , biochemistry , ecology , organic chemistry
Knowledge of the relationship between the quantity of endogenous zinc (Zn) excreted in the feces (EFZ, mg/d) and the quantity of exogenous Zn absorbed (TAZ, mg/d) at that time is necessary for estimating physiologic requirements for Zn. The objective of this project was to reevaluate this relationship utilizing all available total diet data (means), including new data since the publication of Dietary Reference Intakes for Zn. There were 30 datum including 11 male (M), 18 female (F) and 1 mixed gender. Results of linear regression analysis of EFZ vs TAZ and of TAZ at intercept a are summarized in the table: a intercept of regression line for EFZ + other endogenous Zn losses versus TAZ with line of equality; b intercept based on using F other endogenous losses. Lack of significant positive slope for F data is offset by higher y‐intercept resulting in similar intercepts for the F and combined data. The resulting difference in estimation of physiologic requirement for F is only 0.2 mg Zn/d, with actual figures depending on constants used for secondary routes of endogenous Zn excretion. The observed difference between M and F slopes and intercepts has no apparent physiologic explanation but could be attributable in part to limited range of TAZs for F data.