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Adherence to 2005 Dietary Guidelines for Americans was associated with reduced progression of coronary‐artery atherosclerosis in women with established coronary artery disease
Author(s) -
Imamura Fumiaki,
Jacques Paul F,
Herrington David M,
Dallal Gerard E,
Lichtenstein Alice H
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.214.4
Subject(s) - medicine , coronary atherosclerosis , coronary artery disease , cardiology , coronary arteries , coronary heart disease , artery
Criterion‐based dietary indices generally have an untested assumption that all index components have equal health contributions. This assumption was tested for the association between adherence to 2005 Dietary Guidelines for Americans (DGA) and atherosclerosis progression, using data from 225 postmenopausal women with established heart disease in the Estrogen and Atherosclerosis Progression Trial conducted between 1996 and 2000. At the baseline and endpoint, diameters of coronary arteries were measured by quantitative angiography. Adherence to the key DGA recommendations was measured by the DGA Adherence Index (DGAI), where each component was weighted equally, and the modified DGAI (wDGAI), where each component was weighted by its relation to atherosclerosis progression. By mixed model regression analyses, the DGAI was found not associated with atherosclerosis progression (p=0.44). In contrast, wDGAI was inversely associated; one standard deviation difference of wDGAI was related to 0.049 mm less narrowing of coronary arteries (p=0.004). Adherence to the DGA recommendations assigned differential weights based on their relationships with the outcome was significantly associated with reduced atherosclerosis progression. Assuming equity of associations of all DGA recommendations with health outcomes may limit our ability to identify relationships of the DGA with chronic disease prevention. Grant Funding Source U.S. Department of Agriculture, Agricultural Research Service (No. 58‐1950‐7‐707)