Premium
SIRT1, metabolism and calorie restriction
Author(s) -
Bordone Laura
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.197.2
Subject(s) - calorie restriction , biology , metabolism , phenotype , cell metabolism , microbiology and biotechnology , nad+ kinase , sirtuin 1 , sirtuin , genetics , biochemistry , endocrinology , downregulation and upregulation , gene , enzyme
The Sirtuins NAD‐dependent family of deacetylases has been shown to mediate important diverse biological processes including extension of lifespan in multiple species including yeast, C. elegans , and Drosophila. Among the 7 mammalian sirtuins, SIRT1 regulates many important cellular processes, including cell survival, glucose homeostasis and fat metabolism. In particular, SIRT1 has been shown to mediate some of the effects of calorie restriction. In this talk I will discuss a mouse model that overexpresses SIRT1 that show phenotypes resembling calorie restriction. In addition, I will discuss the role that SIRT1 plays in metabolism, especially in the regulation of insulin secretion. These studies help to elucidate the major role that SIRT1 plays in metabolism and calorie restriction.