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Shp2 dependent FGF signaling in retinal development
Author(s) -
Zhang Xin
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.176.3
Subject(s) - fibroblast growth factor , eye development , biology , microbiology and biotechnology , retinal , optic vesicle , retina , signal transduction , protein tyrosine phosphatase , retinal pigment epithelium , receptor tyrosine kinase , genetics , neuroscience , receptor , phenotype , gene , biochemistry
From Drosophila to mammals, the retina develops in a conserved wave‐like pattern emanating from optic stalk to peripheral region. While Drosophila retinal differentiation is regulated by Hedgehog and Receptor Tyrosine Kinase (RTK) signaling in a sequential‐induction fashion, whether such mechanism applies to vertebrate retinal development remains controversial. Previous studies have also implicated Fibroblast Growth Factor (FGF) signaling in specifying retina versus retinal pigmented epithelium (RPE) fate during early eye development, but the molecular mechanism of such profound effect of FGF signaling is still lacking. Shp2 protein tyrosine phosphatase is a critical mediator of many RTK pathways, including FGF signaling. We have determined the mechanism of FGF signaling in retinal development by studying the genetic ablation of Shp2, providing compelling genetic evidence that Shp2 is dispensable for the retinal differentiation wave or maintenance of retinal cell fate. In contrast, our results suggest that Shp2 signaling functions in early patterning of the optic vesicle.