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Effect of vitamin D supplementation on calcium absorption and retention in adolescent girls
Author(s) -
Park Clara Yongjoo,
Hill Kathleen M,
Elble Ann E,
Martin Berdine R,
Peacock Munro,
McCabe George P,
Weaver Connie M
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.112.5
Subject(s) - calcium , vitamin d and neurology , calcium metabolism , endocrinology , crossover study , medicine , calcitriol , chemistry , parathyroid hormone , vitamin , excretion , urine , absorption (acoustics) , zoology , biology , physics , alternative medicine , pathology , acoustics , placebo
In adolescents, cross‐sectional studies show either no or negative relationship between vitamin D status and calcium absorption. Through a crossover‐design metabolic balance study, we investigated the effect of vitamin D supplementation on calcium absorption and retention in adolescent girls (mean serum 25(OH)D: 19.83 ng/ml). Sixteen girls age 11‐14 yrs consumed a controlled diet (providing 400 IU vitamin D and 1136 mg Ca/d) for two 3‐week metabolic balance periods separated by a 1‐week washout period. Sunlight exposure was minimized by sunscreen with a sun protection factor = 15. After the first metabolic balance period, subjects received 1000 IU vitamin D 3 /d supplementation for 4 weeks. Calcium absorption was measured each metabolic balance period using a stable calcium isotope method and indirectly through a 5‐hr PTH suppression profile. All urine and fecal samples were collected and analyzed to measure calcium retention. Statistical analysis was done by repeated measures ANOVA. Vitamin D supplementation resulted in a mean increase in serum 25(OH)D of 4.65 ng/ml (p=0.0007), but it had no effect on serum fasting 1,25(OH) 2 D (p=0.72), calcium absorption (p=0.33), PTH suppression (p=0.92), or calcium retention (p=0.10). Vitamin D supplementation at 1000 IU/d did not affect calcium homeostasis in pubertal girls with vitamin D status levels considered suboptimal in adults. Grant Funding Source Delavau, LLC