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Effect of protein intake and weight loss on bone in overweight‐obese postmenopausal women
Author(s) -
Sukumar Deeptha,
Zurfluh Robert,
Kwon Jane,
Schneider Stephen,
Stahl Theodore,
Shapses Sue
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.108.4
Subject(s) - overweight , weight loss , bone mineral , endocrinology , medicine , osteoporosis , parathyroid hormone , bone remodeling , obesity , postmenopausal women , dual energy x ray absorptiometry , bone density , calcium
High protein intake is a popular method to achieve weight (wt) reduction; however its effect on bone remains controversial. Understanding whether dietary protein intake influences bone mass during caloric restriction was the goal in this study while controlling for dietary calcium. We examined 40 postmenopausal women (58 ¡À 5 years; BMI of 32.4 ¡À 5.7 kg/m2), who were assigned to caloric restriction and 1.2 g Ca/day with either a normal (NP, 18%, n =20) or higher (HP, 30%, n =20) protein intake and a low fat intake (28%). Bone measurements using dual energy x‐ray absorptiometry were performed at baseline, and 6 and 12 months after wt loss. Here we report the data after 6 months of wt loss (‐7.3 ¡À 4%) that did not differ significantly between groups. Total body bone mineral density and lumbar spine bone mineral content decreased (p<0.05) more in the NP (‐2.0% and ‐1.6% respectively) compared to HP group (‐0.1 % and 1.2% respectively). In a subset of women (n=22), bone turnover markers were measured and showed no changes, but there was a trend (p¡Ü0.08) for a greater increase in serum 25‐hydroxyvitamin D and parathyroid hormone in the NP than HP group, that requires confirmation in the entire group. These data suggest that higher dietary protein attenuates bone loss during wt reduction in postmenopausal women. Further analysis of the mechanisms mediating these changes is being addressed. SUPPORT: NIḦCAG12161, Busch Biomedical Grant Grant Funding Source NIA‐NIH