Premium
Manipulation of lipid bioaccessibility influences postprandial vitamin E concentrations in healthy human subjects: implications for inflammation, oxidative stress and vascular responses.
Author(s) -
Berry Sarah E,
Lapsley Karen,
Tydeman Elizabeth A,
Lewis Hannah B,
Phalora Ravneet,
Rosborough Jennifer,
Picout David R,
Ellis Peter R
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.103.3
Subject(s) - postprandial , oxidative stress , medicine , vitamin e , endocrinology , vitamin , antioxidant , inflammation , meal , sunflower oil , chemistry , food science , biochemistry , diabetes mellitus
Postprandial lipemia is associated with an acute elevation in oxidative stress, inflammation and impaired vascular function, which is attenuated by the presence of antioxidant vitamins. We previously reported that slow release (low bioaccessibility) of lipid from whole almonds (WA) during digestion, compared with free oil from almond (AO) or sunflower (SO) seeds, reduced postprandial lipemia (over 8h), but no effects on oxidative stress and vascular function were found 1 . Subjects (n=20, aged 18‐40y) were fed test meals containing 50g fat provided as WA, AO or SO in a randomised cross‐over design, with 1‐wk washout. Additional analysis to investigate the effects of differences in lipid bioaccessibility on changes in plasma vitamin E and interleukin 6 (IL‐6; inflammatory marker) concentrations are presented. Plasma vitamin E concentrations were lower (mean incremental area under curve with 95% CI) following the WA meal (69 (25, 113)) vs. the AO (150 (211, 88)) and CO (137 (190, 84)) meals; P=0.003. IL‐6 concentrations increased significantly from fasting following the test meals (P=0.023), but did not differ between meals. The concomitant increase in plasma vitamin E with postprandial lipemia from the free oils may counterbalance the deleterious effects of exaggerated lipemia on oxidative stress, inflammation and vascular function. 1 Berry et al. Am J Clin Nutr 2008;88:922‐9