Premium
The threshold of central ghrelin induced anorexia is lower in chicks selected for low rather than high body weight
Author(s) -
Calchary Wendy Alyssa,
Siegel Paul,
Cline Mark
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.1022.16
Subject(s) - ghrelin , anorexia , food intake , medicine , endocrinology , body weight , chemistry , biology , zoology , hormone
Ghrelin is a gut derived 28 amino acid peptide that when centrally injected stimulates food intake in mammals, but decreases food intake in avians. The present study was designed to determine the effects of central ghrelin in lines of chickens that have undergone long term divergent selection for low (LWS) or high (HWS) body weight. In experiment one, chicks in line LWS responded to all doses of central ghrelin injected (0.083, 0.33, 1.33 nmol) with decreased food intake during the 180 min observation time , while line HWS chicks only responded to 0.33 and 1.33 nmol central ghrelin with decreased food intake. The dose of 0.33 nmol ghrelin only significantly reduced food intake in line HWS after 120 min post injection. In experiment two, central ghrelin injection was associated with a greater magnitude suppression of standing and perching time and feeding and exploratory pecks in line LWS than line HWS. Additionally, the magnitude of increased sitting and deep resting time was higher in line LWS. These results support the thesis that the magnitude of centrally induced ghrelin associated anorexia is different between lines LWS and HWS and differential behavior responses may contribute to this effect.