Premium
Octreotide acetate moves the volume indifferent point
Author(s) -
Jarvis Sara Sun,
Pawelczyk James
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.1019.9
Subject(s) - splanchnic , medicine , octreotide , blood volume , endocrinology , somatostatin , blood flow
During head‐up tilt (HUT), gravity redistributes ~700 mL of blood to the legs, abdomen, and pelvis, decreasing venous return. The location of the volume indifferent point (VIP) provides a quantitative assessment of this volume redistribution and coincides with the hydrostatic indifferent point (HIP). A more superior VIP/HIP should relate to improvements in HUT tolerance as cardiac filling is enhanced. Previously we noted that administration of octreotide acetate, a selective splanchnic vasoconstrictor, improved HUT tolerance. In this study we determined the location of VIP, with and without octreotide acetate. Blood volume shifts were determined with segmental impedance and were regressed against the distance of each segment from the feet. The point where blood volume did not change was defined as the VIP. The VIP was located 64.5 ± 2.6% of an individual's height. Administration of octreotide acetate resulted in a superior shift of the VIP (1.9 ± 3.3 cm, p=0.03). Taken together, these studies suggest that selective splanchnic constriction induced by octreotide acetate alters blood volume distribution during HUT, improving tilt table tolerance by shifting the VIP to a more superior location.