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Bioimpedance measurements to determine fluid volume distribution in desoxycorticosterone acetate (DOCA)‐salt hypertension
Author(s) -
Seitz Bridget Mahon,
Fink Gregory
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.1017.7
Subject(s) - medicine , blood pressure , distilled water , splanchnic , anesthesia , blood volume , hemodynamics , endocrinology , chemistry , chromatography
Splanchnic arterial and venous constriction promotes redistribution of blood volume from the abdominal region into the central circulation and thereby into less compliant vascular beds. We hypothesized that this mechanism contributes to the development of DOCA‐salt hypertension. Bioimpedance was used to estimate blood volume translocation in rats by permanently implanting electrodes in pairs across the chest and abdomen. Radiotelemetry transmitters were also surgically implanted to simultaneously measure blood pressure. In addition, all animals underwent a uninephrectomy and a control period of distilled water intake. Some rats were switched to high salt water for 3 days and then implanted with a DOCA pellet. After 5 days DOCA rats were then switched back to distilled water. Arterial pressure did not change during the control or high salt intake alone. Administration of DOCA to rats on high salt intake caused a slow increase in arterial pressure. There were no changes in impedance in the thoracic region in either group of rats during the study. However, there was a two‐fold increase in impedance (most likely indicating decreased blood volume) in the abdominal region during the onset of DOCA‐salt hypertension, which was reversed when rats were given distilled water. We conclude that blood translocation from the abdominal region may participate in the development of DOCA salt hypertension.