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Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in conscious rats
Author(s) -
OliveiraSales Elizabeth B,
Toward Marie Ann,
Campos Ruy Ribeiro,
Paton Julian FR
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.1017.16
Subject(s) - baroreflex , medicine , blood pressure , cardiology , autonomic nervous system , clipping (morphology) , pulse pressure , sympathetic nervous system , vasomotor , heart rate , anesthesia , linguistics , philosophy
Despite the extensive use of the Goldblatt model of hypertension (two kidney one clip, 2K‐1C) autonomic nervous mechanisms responsible for both the development and maintenance of the hypertension remain unclear. The objective of this study was to analyse cardiovascular autonomic function by power spectral density analysis of arterial pressure and pulse interval measured by radio telemetry for 6 weeks after renal artery clipping. Mean arterial pressure increased from 106±5 to 185±2 mmHg five weeks post clipping (n=6; P<0.05) remaining stable during the 6 th week. A tachycardia developed during the 4 th week from 406±7 bpm which plateaued by weeks 5 and 6 at 468±10 bpm. The gain of the parasympathetic component of the cardiac baroreflex decreased gradually until the 5 th week (from ‐2.4±0.09 to ‐0.8±0.04 bpm/mmHg) when it plateaued, and high frequency power spectral density of the pulse interval decreased from 13.4±0.6 to 8.3±0.01 ms 2 . In addition, there was an increase in both the low frequency and very low frequency components of the spectra of systolic blood pressure that did not occur until 3 weeks after clipping. The results indicate that 2K‐1C hypertension is associated with: (i) an immediate alteration in cardiac autonomic control characterized by a sympathetic predominance and decreased baroreflex sensitivity; (ii) elevated sympathetic vasomotor drive occurring 3 weeks post clipping that persists into the 6 th week. Supported by CAPES.