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Impaired pressure‐natriuresis relationship precedes the development of hypertension in Cyp1a1‐Ren‐2 transgenic rats
Author(s) -
Cervenka Ludek,
Thumová Monika,
Husková Zuzana,
Vanecková Ivana
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.1016.5
Subject(s) - natriuresis , medicine , endocrinology , blood pressure , renal function , renin–angiotensin system , chemistry
Objective The present study was performed to characterize the autoregulatory efficiency of renal blood flow (RBF) and glomerular filtration rate (GFR) and the pressure‐natriuresis relationship in transgenic rats with inducible hypertension (Cyp1a1‐Ren‐2 rats). Methods The renin gene was induced in Cyp1a1‐Ren‐2 rats trough dietary administration of the natural xenobiotic indole‐3‐carbinol (I3C, 0.3 %) for 12 hours. Non‐induced rats served as controls. Anesthetized rats were prepared for renal function studies and an aortic clamp was placed on the aorta to regulate the level of renal arterial pressure. ANG II levels were measured by radioimmunoassay. Results Administration of I3C resulted in progressive increases in ANG II levels as compared with non‐induced rats. I3C‐induction for 12 hours did not cause significant changes in blood pressure as compared with non‐induced rats. 12 hours I3C‐induction caused an impairment of the autoregulatory efficiency of RBF and GFR and of the pressure‐natriuresis relationship as compared with non‐induced rats. Conclusions Our findings indicate that an impairment of the pressure‐natriuresis mechanism precedes the development of ANG II‐dependent hypertension in Cyp1a1‐Ren‐2 transgenic rats.