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Effects of food form and resistance training on postprandial appetitive sensations and ghrelin, cholecystokinin, and glucagon‐like peptide‐1 in older adults
Author(s) -
Apolzan John W,
Leidy Heather J,
Mattes Richard D,
Campbell Wayne W
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.101.8
Subject(s) - ghrelin , postprandial , sed , medicine , endocrinology , cholecystokinin , peptide yy , appetite , chemistry , hormone , neuropeptide , insulin , neuropeptide y receptor , receptor
This study assessed the effects of food form (FF) and resistance training (RT) on appetitive sensations and postprandial (PP) plasma hormones in 16 RT and 18 sedentary (Sed) persons: age 62‐84 y; physical activity 425 ± 33 vs. 272 ± 28 kcal/d (*, p=0.05), mean ± SE; BMI 24.0 ± 0.6 vs. 25.7 ± 0.5* kg/m 2 ; and whole body maximum strength 8.3 ± 0.3 vs. 6.7 ± 0.3* kg/kg fat free mass. On 2 randomized days, each subject consumed an isoenergetic macronutrient‐matched beverage (B) or solid (S) product. 4‐h PP measurements were assessed using area under the curve. Fullness was lower for B (218 ± 94) vs. S (475 ± 96* AU·240 min) and was lower in RT (230 ± 118) vs. Sed (450 ± 106*). Desire to eat was higher for B (‐65 ± 97) vs. S (‐331 ± 114* AU·240 min) but unaffected by RT. The hunger response tended to be higher for B vs. S (p=0.07). FF and RT did not affect ghrelin. CCK was lower in B (6.2 ± 8.9) vs. S (33.4 ± 8.9* ng/mL·240min) and higher with RT (29.0 ± 12.7) vs. Sed (12.2 ± 7.7*). GLP‐1 tended to be higher in B (37.1 ± 19.2) vs. S (0.9 ± 11.3 ng/mL·240min, p=0.06) and was lower in RT (3.9 ± 3.2) vs. Sed (31.6 ± 22.4*). GLP‐1 and ghrelin were negatively correlated with fullness (r=‐0.15*, r=‐0.18*). Ghrelin was positively correlated with hunger (r=0.16*) and desire to eat (r=0.15*). These results suggest that FF and RT influence appetitive sensations and hormonal responses. Older adults may benefit from incorporating RT and B meals to potentially reduce the anorexia of aging. Grant Funding Source NIH R01 AG021911 , The Solae Company, Purdue Bilsland Fellowship