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TAS2R50 genotype and dietary preferences
Author(s) -
Asik Christine,
Eny Karen,
Herd Sarah,
Lee Hyeon Joo,
ElSohemy Ahmed
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.101.2
Subject(s) - genotype , grapefruit juice , taste , food science , population , allele , cruciferous vegetables , biology , medicine , genetics , gene , bioinformatics , environmental health , cancer , pharmacokinetics
The TAS2R50 gene belongs to the TAS2R taste receptor family, which mediate bitter taste perception. The objective of this study was to determine if genetic variation in TAS2R50 is associated with differences in dietary preferences. Individuals (n=967) between the ages of 20 and 29 years completed a food preference checklist to rank their liking/disliking of 24 bitter foods and beverages on a 9‐point scale. Subjects who reported the lowest 3 points were classified as disliking. DNA was isolated from blood samples and genotyped for a polymorphism in TAS2R50 (rs2900554, G>T). In this population, the frequency of the G and T alleles were 36.8% and 63.2%, respectively. The TAS2R50 genotype was strongly associated with different preferences for grapefruit and grapefruit juice. Individuals with the GG genotype were most likely to report disliking grapefruit followed by individuals with the GT and TT genotypes (30.0%, 15.8%, 7.8%; p<0.0001). Similar effects were observed for grapefruit juice (33.3%, 18.7%, 14.9%; p<0.0001). TAS2R50 genotypes were also associated with differences in preference for kale (p=0.008), spinach (p=0.01), turnip (p=0.03) and bitter sweet chocolate (p=0.05). These results indicate that common variations in the TAS2R50 gene are associated with differences in preference for grapefruit and other bitter tasting foods and may explain inter‐individual differences in the consumption of these foods. Grant Funding Source The Advanced Foods and Materials Network