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HLA Class II Haplotype Association with Variations in Regulatory T Cells in Systemic Lupus Erythematosus
Author(s) -
Suggs Jeanann,
Cruse Julius M,
Lewis Robert E,
Majithia Vikas
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.23.1_supplement.1004.5
Subject(s) - foxp3 , il 2 receptor , immunology , haplotype , allele , biology , regulatory t cell , population , human leukocyte antigen , immune system , genetics , t cell , medicine , gene , antigen , environmental health
Clinically diagnosed SLE cases consisting of predominantly African American females were studied for HLA trends and composition of regulatory T cells. Class II DRB1 typing revealed that 30.8% of this population harbored at least one DRB1*1503 allelic haplotype. This 1503 subgroup exhibited a higher rate of serositis than did the non‐1503 subgroup. Flow cytometric analysis of lymphocyte populations did not demonstrate a difference among the CD4 + /FoxP3 + /CD25 + staining regulatory T cells between the two subgroups. However, a significantly higher proportion of CD4 + /FoxP3 + /CD25 − and CD4 + /FoxP3 + /CD25 variable populations were found in the 1503 haplotype group than in to the non‐1503 group. This suggests a possible role for CD25 (IL‐2Rα) in the disease manifestations for this subgroup, and future studies will focus on other regulatory T cell surface markers, and whether activation, proliferation, and homeostasis of the immune reaction is compromised in the 1503 subgroup due to the decreased expression of CD25.