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A Randomized, Double‐Blind, Placebo‐Controlled Clinical Effect of a Xanthone‐rich Dietary Supplement on Immune Function in Humans: A Randomized Double‐Blind Placebo‐Controlled Trial
Author(s) -
Tang YuPing,
Li PengGao,
Ji Hongping,
Kou Yan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.804
Subject(s) - immune system , medicine , placebo , multivitamin , randomized controlled trial , clinical trial , lactoferrin , immunology , physiology , vitamin , biology , pathology , alternative medicine , genetics
Use of multivitamin, minerals and antioxidants supplements may delay the aging of the immune system. However, controversies surrounding the use of supplements still exist. The objective of this clinical trial was to determine whether daily consumption of VemmaTM, a xanthone‐rich juice enriched with 12 vitamins, selenium, green tea catechins aloe vera polysaccharides and trace and ultra trace minerals can: 1. Delay the aging of the immune system; 2. Decrease the inflammatory biomarkers; 3. Improve wellbeing in humans. A randomized, placebo‐controlled, double‐blinded, parallel‐group trial involving 59 community‐dwelling healthy adults. Primary outcome measure was the changes in peripheral blood T lymphocytes subsets percentages after 30 days. Secondary outcome measures were changes in serum cytokines, immunoglubolins, complements and C‐reactive proteins (CRP) as well as the subjects¡¯ self‐ appraisal on their health status. Data indicate that intake of VemmaTM effectively : 1. Increased biomarkers of both cellular and humoral immune systems; 2. Reduced inflammatory biomarkers; 3. Improved the subject¡¯s self‐appraisal on their health status, indicating that the juice may be able to: 1. Delay age‐related decline in immune function; 2. Improve the defense against infectious diseases; 3. Improve life quality.