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Bioavailability and Antioxidant Effects of A Xanthone‐rich Dietary Supplement in Humans
Author(s) -
Ou Boxin,
Ji Hongping,
Kou Yan,
Kondo Miwako
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.803
Subject(s) - oxygen radical absorbance capacity , antioxidant , bioavailability , chemistry , food science , oxidative stress , pharmacology , traditional medicine , antioxidant capacity , biochemistry , medicine
Oxidative damage is involved in many chronic diseases including the major causes of death in western societies such as cardiovascular disorders and cancer. Antioxidants may prevent these degenerative processes by various mechanisms including the scavenging of free radicals. Intake of antioxidant supplements is associated with preventing oxidative damages. This study investigated the absorption and antioxidant effects of a liquid dietary supplement (VEMMA™) in healthy human volunteers after the acute consumption of 60 ml the supplement. VEMMA™contains mangosteen extract, green tea extract, minerals and multi vitamins Results indicate that α‐mangostin, Vitamins B2, B3 and B5 are bioavailable, with observed C max at t max of around 1 hour. The antioxidant capacity measured with the oxygen radical absorbance capacity (ORAC) assay was increased with a maximum effect of 10% after 2 hours and the increased antioxidant level lasted at least 4 hours. Overall, this study demonstrated the bioavailability of antioxidants from VEMMA™ and its in vivo antioxidant effects.