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Relationship of uric acid to markers of metabolic syndrome (MS) and medical status
Author(s) -
Beavers Kristin,
Chandran R,
Jitomir J,
Shelmadine B,
Kerksick C,
Wilborn C,
Wismann J,
Nassar E,
Dove J,
Galbreath M,
La Bounty P,
Campbell B,
Ferreira M,
Cooke M,
Iosia M,
Rasmussen C,
Bowden R,
Wilson R,
Kreider R
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.786
Subject(s) - uric acid , waist , medicine , endocrinology , body mass index , metabolic syndrome , triglyceride , circumference , cholesterol , obesity , geometry , mathematics
543 sedentary women (44±11 yrs, 92±17 kg; 45±4% body fat) were medically screened prior to participation in an exercise and weight loss program. Subjects were divided into those with less than (n=281) or more than (n=262) three criteria for MS. Medical data and fasting blood samples were collected and analyzed by one‐way ANOVA for the non‐MS and MS groups, respectively. Women with MS had significantly (p<0.001) higher uric acid levels (4.55±1.1 vs 5.28±1.3 mg/dl). Uric acid levels significantly correlated (p<0.001) with body mass (r=0.150), BMI (r=0.26), waist circumference (r=0.153), hip circumference (r=0.139), bone mineral content (r=0.126), DEXA body fat percent (r=0.096), HDL (r=‐0.091), glucose (r=‐0.122), and resting energy expenditure (r=0.143). Additionally, uric acid levels significantly correlated with the women who met MS criteria for waist circumference (r=0.092, p=0.03), blood pressure (r=0.088, p=0.04), and women with 3 or more criteria for MS (r=0.129, p=0.003). Uric acid levels were not significantly correlated with age, height, resting HR, resting BP, triglycerides, total cholesterol, LDL, or maximal oxygen uptake. While correlations were modest, these finding suggest a relationship between uric acid and several markers of metabolic syndrome in sedentary women.