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GoChi™, a standardized Lycium barbarum (goji) juice, shows significant in vivo antioxidant effects in human serum in a randomized, double‐blind, placebo‐controlled clinical study
Author(s) -
Amagase Harunobu,
Sun Buxiang
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.781
Subject(s) - lycium , placebo , antioxidant , in vivo , traditional medicine , double blind , medicine , food science , pharmacology , chemistry , biology , microbiology and biotechnology , biochemistry , pathology , alternative medicine
Several in vitro methods purport to assess the antioxidant capacity of foods or supplements. However, a high antioxidant score in vitro may not translate to increased antioxidant status in vivo . Maintaining high levels of endogenous serum antioxidants ‐ superoxide dismutase (SOD) and glutathione related enzymes ‐ is more meaningful to human health. This randomized, double‐blind, placebo‐controlled human trial is the first clinical study to show actual antioxidant effects of orally consumed Lycium barbarum fruit (goji), administered as a standardized juice (GoChi™) in 50 healthy adults between 55–72 years of age. SOD, glutathione peroxidase (GSH‐Px) and malondialdehyde (MDA) were examined in human serum before and after consuming 120 ml/day of GoChi or placebo for 30 days. Serum SOD in the GoChi group was significantly increased over placebo, with an increase of 8.4% compared to the baseline; GSH‐Px was increased by 9.9% and MDA was decreased by 3.4% compared to the baseline. No significant differences were detected in the placebo group. These results clearly indicate that daily consumption of GoChi increases antioxidant efficacies in humans by stimulating endogenous factors.