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Elevated plasma folate concentrations and dietary folate are associated with overall survival after breast cancer diagnosis
Author(s) -
McEligot Archana Jaiswal,
Ziogas Argyrios,
AntonCulver Hoda
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.775
Subject(s) - medicine , quartile , breast cancer , proportional hazards model , body mass index , cancer , physiology , gastroenterology , confidence interval
The present study investigated the association between elevated serum folate concentrations and dietary folate intake with overall survival after breast cancer. Participants were post‐menopausal women diagnosed with breast cancer (n = 499) with a mean follow‐up of 80 months. Total serum folate concentrations collected at or post diagnosis were measured by radio protein binding assay, and dietary data were self‐reported via a food frequency questionnaire. Stage of disease, age at diagnosis, ER/PR status and death from any cause were obtained through a cancer registry. Cox proportional hazards models were used to measure the relationship between serum folate and dietary folate with risk of dying (due to any cause) after breast cancer diagnosis. In the multivariate analysis [controlled for disease stage, age at diagnosis, body mass index (BMI), parity, ER/PR status, alcohol use and energy intake], we found that the relative risk of dying in the highest quartile was nearly 50% lower (RR: 0.53, 95% CI: 0.29 – 0.95) compared with all other groups (1 st , 2 nd and 3 rd quartile). There was a reduced risk of dying in the highest quartile of dietary folate intake (RR: 0.39, 95% CI: 0.17 – 0.89) compared with the lowest quartile. These results suggest that circulating folate concentrations at and/or after diagnosis, and increasing dietary folate intake are associated with overall survival after breast cancer diagnosis. Supported by NCI grant K07 CA101964.