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Zinc (Zn) absorption from a dispersible zinc sulfate tablet
Author(s) -
Kraushaar Hatai Ann,
Hambidge K Michael,
Miller Leland V,
Westcott Jamie E,
Lei Sian,
Tran Cuong D,
Krebs Nancy F
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.749
Subject(s) - zinc , bioavailability , sulfate , chemistry , absorption (acoustics) , aqueous solution , nuclear chemistry , radiochemistry , pharmacology , materials science , medicine , composite material , organic chemistry
Background: Dispersible zinc sulfate tablets (Nutriset, Malaunay, France) are widely used for zinc supplementation worldwide. However, to our knowledge, there have been no human studies on the bioavailability of the zinc in these tablets. Objective: To determine if the amount of zinc absorbed from a dispersible zinc sulfate tablet is comparable to published data for similar doses of aqueous zinc sulfate. Methods: In this pilot study, one healthy male adult subject in a post‐absorptive state was orally administered a 10 mg dispersible zinc sulfate tablet labeled with 70 Zn. An IV dose of 67 Zn was administered 1 hr later. Fractional absorption of zinc (FAZ) was determined by a dual isotope ratio technique based on urine isotope enrichment. Ingested zinc (IZ) = measured zinc in tablet and oral isotope dose. Absorbed zinc (AZ) = FAZ × IZ. AZ was compared to a previously published saturation response model that relates the amount of zinc absorbed to the amount of aqueous zinc sulfate ingested (Tran et al., AJCN, 2004). Results: FAZ = 0.61 and IZ = 10.5 mg, therefore AZ = 6.4 mg. This AZ falls within the range predicted for a similar dose of aqueous zinc sulfate (if IZ = 10.5 mg, AZ = 7.6 mg ± 1.2 mg). Conclusion: The amount of zinc absorbed from a dispersible zinc sulfate tablet is comparable to that from aqueous zinc sulfate. Funded by NIH Grants K24 RR018357 and R01 HD053053.