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Insulin resistance in a HIV+ pediatric population
Author(s) -
Culp Jenna L.,
Borum Peggy R.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.748
Subject(s) - insulin resistance , medicine , population , quantitative insulin sensitivity check index , diabetes mellitus , human immunodeficiency virus (hiv) , insulin , type 2 diabetes , insulin sensitivity , pediatrics , endocrinology , environmental health , immunology
Insulin resistance (IR) is not regularly monitored in pediatrics due to a perceived lack of risk for developing IR and resultant type 2 diabetes. Due to recent increases in diagnoses of type 2 diabetes, IR is becoming a larger concern for the pediatric population. HIV and associated antiretroviral therapy may increase the risk of developing IR. A positive Cumulative Indices Assessment (+CIA), the average of the percent difference from the respective thresholds of five common indices used to assess risk of developing IR, confers a risk of IR. These indices are fasting glucose to insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment (HOMA‐IR), insulin sensitivity index (ISI), and the ratio of triglycerides to high‐density lipoprotein (TG/HDL). We found a +CIA in 22% of 37 HIV+ pediatric patients seen between 2005 and 2007 at Shands Children's Hospital at the University of Florida. The table below shows parameters which are associated with a +CIA and, therefore, could be used to select patients for IR monitoring if it is not possible to monitor the entire population.