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Anti‐adipogenic effect of Heloniopsis orientalis in 3T3‐L1 cells
Author(s) -
LEE HYUNJUNG,
KIM SUNA,
PARK JAEHO,
HA TAEYOUL,
AHN JIYUN
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.711
Subject(s) - adipogenesis , lipogenesis , endocrinology , 3t3 l1 , medicine , obesity , triglyceride , adipocyte , type 2 diabetes , downregulation and upregulation , chemistry , oil red o , intracellular , dyslipidemia , diabetes mellitus , biology , cholesterol , adipose tissue , biochemistry , gene
Obesity has become the leading metabolic disease in the world and caused serious health problems like type 2 diabetes, cardiovascular disease, dyslipidemia, cancer and respiratory complication. It has been suggested that decreased preadipoctye differention, proliferation and lipogenesis are mechanisms to reduce obesity. In the present study, we explored the effect of Heloniopsis orientalis ( H. Orientalis ) on the adipogenesis of 3T3‐L1 cells. Treatment of differenting adipocyte with 0.1, 0.5 and 1 mg/ml H. orientalis inhibited 3T3‐L1 differentiation in a dose‐dependent manner. H. Orientalis decreased the intracellular triglyceride accumulation. Moreover, treatment with H. orientalis decreased the expression of adipogenesis related molecules incluing C/EBPα, SRECP‐1, FAS and PPARγ. These results demonstrate that H. Orientalis effectively inhibited adipogenesis in 3T3‐L1 preadipocytes and thus, could be an important adjunct in the treatment of obesity.