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The effect of conjugated linoleic acid (CLA) on the levels of apoptotic proteins and fatty acid ethyl esters (FAEEs) in the brain of chronic ethanol‐treated rat
Author(s) -
Kim Minseok,
Kim Sena,
Jeong Jae Hoon,
Park HyunSuh
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.703
Subject(s) - conjugated linoleic acid , chemistry , apoptosis , ethanol , liquid diet , medicine , endocrinology , fatty acid , ingestion , linoleic acid , caspase 3 , biochemistry , biology , programmed cell death
SD rats were divided into three groups; Control, EtOH, EtOH+CLA. All rats were fed Lieber‐DeCarli liquid diet (36%Kcal) for 4 wk by pair‐feeding. Liquid diet of EtOH+CLA groups was supplemented with 1.77 g CLA mixture per kg diet. Chronic ethanol ingestion did not alter the levels of Bax and Bcl‐2 proteins and FAEEs, but significantly increased the level of Caspase 3 protein by reducing the ratio of Bcl‐2/Bax. Compared to the EtOH group, whereas, CLA supplementation significantly increased the content of 9,11‐CLAEEs and thereby significantly increased the Bcl‐2/Bax ratio, and consequently reduced the level of Caspase 3 protein. In conclusion, the biological functions and specific mechanism of CLAEEs are not yet fully understood. However, the increase of 9,11‐CLAEEs in the brain may play an important role in reducing the level of apoptosis.