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A Clinical Evaluation Comparing the Bioavailability of Two Buffered Vitamin C Supplements in Healthy, Non‐smoking Males.
Author(s) -
Labiste Kirenia,
Feldman Samantha,
Krieger Diane R.,
Kalman Douglas
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.689
Subject(s) - bioavailability , ingestion , urine , high performance liquid chromatography , vitamin c , vitamin , chemistry , absorption (acoustics) , zoology , medicine , food science , chromatography , pharmacology , biochemistry , biology , physics , acoustics
Purpose: To determine and compare the relative bioavailability of vitamin C (AA) from Comfort C® and Ester‐C® in healthy, non‐smoking, young males. Methods: Five males (32.0 ± 6.2 years) received a single, 1 gram dose of AA from 2 different AA products in random order, EACH dose preceded by at least 7 days of a low AA diet. Blood was drawn pre‐ingestion and 30, 60, 90, 120, 210 and 240 minutes post‐ingestion for serum AA analysis by HPLC. Average urine concentrations of AA were determined by twenty‐four hour collection and HPLC analysis. Results: Weight adjusted AA concentration changes from baseline were significantly higher with Comfort C than Ester‐C at 60 minutes (4.33±1.47 ug/ml vs 1.68±0.90; p=0.043). Peak AA concentrations tended to be the same between the two products. Urinary AA concentrations did not differ between treatments. Conclusions: Although there were no differences in the overall absorption between the AA products over the 4‐hour test period, with Comfort C displaying a faster rate of absorption than Ester‐C. Sponsored by Scientific Food Solutions, LLC