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Effect of dietary grape peels on tissue contents and fecal excretion of lipids in rats fed high fat diet
Author(s) -
Seo JungSook,
Lee SuJin,
Lee JinKyong
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.687
Subject(s) - triglyceride , excretion , chemistry , lipid metabolism , feces , food science , cholesterol , obesity , grape seed extract , blood lipids , endocrinology , biology , medicine , biochemistry , alternative medicine , paleontology , pathology
The present study was conducted to examine the effect of dietary grape peels on lipid metabolism in obese rats. Male Sprague‐Dawley rats were fed high fat diet for 2 weeks. Rats were divided into 5 groups [Normal(C), Normal+5% grape peel(CP), High‐fat(HF), High‐fat+5% grape peel(HFP) and High‐fat+10% grape peel(HFPP)] of 10 each and fed on AIN‐93 based experimental diets for 4 weeks. Serum level of triglyceride was decreased significantly in grape peel group with high fat compared to control group with high fat. Total cholesterol level was not significantly different among experimental groups. HDL‐cholesterol level of 5% grape peel group with high fat was higher than control group with high fat. The hepatic levels of total lipid and total cholesterol were decreased in grape peel group compared to control group with high fat. Triglyceride level was lower in grape peel group than in control group with high fat. The fecal excretion of total lipid tended to be higher in grape peel group than in control group. The fecal excretion of triglyceride was increased in grape peel group than in control group. These results suggest that dietary supplementation of grape peel would be effective on anti‐obesity activities through improvement of lipid metabolism. This study was supported by the research fund from Yeungnam University.