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Therapeutic efficacy of undenatured type II collagen (UC‐II) in comparison to glucosamine plus chondroitin in arthritic horses
Author(s) -
Bagchi Manashi,
Gupta Ramesh C,
Canerdy Terry D,
Goad John T,
Barnett Dale,
Bagchi Debasis
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.659
Subject(s) - glucosamine , chondroitin , medicine , placebo , arthritis , bilirubin , gastroenterology , chondroitin sulphate , chondroitin sulfate , chemistry , glycosaminoglycan , pathology , biochemistry , alternative medicine , anatomy
Arthritis is a debilitating disease that commonly affects millions of horses. The present investigation evaluated arthritic pain in horses receiving daily placebo, undenatured type II collagen (UC‐II, 80, 120, or 160 mg/day), and glucosamine and chondroitin (5.4 g/day and 1.8 g/day, respectively, bid for the first month, and thereafter once daily) for 150 days. Horses receiving placebo showed no change in arthritic condition, while those receiving 80, 120, or 160 mg UC‐II exhibited significant reduction in arthritic pain (P<0.05). UC‐II at 120 mg dose provided optimal effects. With this dose, reduction in overall pain was from 5.7±0.0.42 (100%) to 0.7±0.42 (12%); and in pain upon limb manipulation from 2.35±0.37 (100%) to 0.52±0.18 (22%). With glucosamine + chondroitin, although reduction in pain was significant compared to pretreated values, but the efficacy was significantly less comared to that observed with UC‐II. UC‐II was found to be twice as effective as glucosamine and chondroitin in arthritic horses. Clinically, physical condition, and liver (ALP, GGT, and bilirubin), kidney (BUN and creatinine), and heart (CK) functions remained unchanged, suggesting that these supplements were well tolerated. These findings demonstrated that UC‐II was significantly more efficacious than glucosamine and chondroitin in arthritic horses.