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EXTRA VIRGIN OLIVE OIL AND VASCULAR HEALTH
Author(s) -
Klaahsen Darcey Lynn,
Zhang Hanrui,
Park Yoonjung,
Lee Sewon,
Hardin Christopher,
Zhang Cuihua
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.63
Subject(s) - vasodilation , sodium nitroprusside , medicine , endocrinology , type 2 diabetes , diabetes mellitus , nitric oxide
Extra virgin olive oil (EVOO) plays pivotal roles on benefiting cardiovascular function. The nonsteroid drug, sodium salicylate (SS), has anti‐inflammatory effects. Accordingly, we hypothesized that the two may have an affect on vascular dysfunction and insulin resistance in Type II diabetes. Methods: To test this hypothesis, we assessed the roles of EVOO and SS in the cardiovascular function of diabetic (Lepr db ) mice and wild‐type (WT) mice (n=5). WT and Lepr db mice were placed on a control diet (AIN 93M), a 20% EVOO diet (w/w), or a standard rodent chow diet for 7 weeks. Coronary arterioles were isolated and pressurized (60 cmH2O) without flow. Results: Although dilation of vessels to the endothelium‐independent vasodilator, sodium nitroprusside, was not different between Lepr db and WT mice, dilation to the endothelium‐dependent agonist, acetycholine (ACh), was reduced (p<0.05). Vasodilation to ACh was partially restored in Lepr db mice dieted with EVOO. Moreover, body weight was 27% lower than the Lepr db ‐chow group (p=0.003). However, blood glucose levels were not improved in the diabetic animals until 10 days treatment with 0.6% SS, after which their blood glucose levels dropped 30%. Conclusion: These results indicate a potential role for EVOO and SS in the management of Type II diabetes in terms of weight gain, glucose tolerance, and vascular function. This study was supported by American Heart Association Scientist Development Grant (110350047A) and NIH grants (RO1‐HL077566 and RO1‐HL085119) to Dr. Cuihua Zhang.