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Depletion Of Circulating Endothelial Progenitor Cells In Normal Subjects With Depression
Author(s) -
Chen Hua,
Jianati Qiuwaxi,
Wong ChingYuen,
Li SheungWai,
Chan HiuTing,
Tam Sidney,
Lau ChuPak,
Tse HungFat
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.59
Subject(s) - depression (economics) , medicine , endothelial dysfunction , population , pulse wave velocity , diabetes mellitus , endothelial progenitor cell , cd34 , cardiology , endocrinology , progenitor cell , stem cell , blood pressure , genetics , environmental health , biology , economics , macroeconomics
Recent studies suggest that depression and circulating endothelial progenitor cells (EPC) are associated with endothelial dysfunction and arteriosclerosis. However, there is no data on the relationship between the level of circulating EPCs and depression status. Methods and Results: We studied 132 healthy normal individuals (55±8 yrs, 59 men) without prior cardiovascular diseases or diabetes. All subjects has coronary artery calcium<10 as assessed by cardiac computed tomography. The numbers of circulating CD34 + EPCs were determined by flow cytometry, and the depression status was estimated by Depression Anxiety Stress Scales. The median depression score of the study population is 4 (range 0 to 34). 42 pts (32 %) had a high depression score as defined by ≥ 75% percentile depression score of all subjects (>=8). There were no significant differences in age (55±9 vs. 54±10 yrs), sex (45 vs. 40 % male) and smokers (30 vs. 29 %) between the subjects with or without high depression score (all P>0.05 ). However, subjects with high depression scores had a significantly lower CD34 + EPC percentage (4.28±2.59 vs. 5.50±3.96 %, P=0.0 37 ) than those without high depression score. CD34 + EPC percentage have a negative correlation with depression score (r=−0.307, P=0.040 ) and a positive correlation with hs‐CRP value (r=0.330, P=0.027 ) and central pulse wave velocity (PWV) (r=0.261, P=0.004 ). Conclusions: Our result demonstrates that depression was associated with a lower level of circulating EPCs in the normal individuals without significant cardiovascular diseases. This finding suggests that depletion of EPC in normal subjects with depression may contribute to the development of arterial stiffness.