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The Jackson Laboratory Repository: New Mouse Models of Inflammation and Cancer/Immunology
Author(s) -
Merriam Jennifer,
Valenzuela A,
Lake J,
Bergstrom D,
Chang B,
Donahue LR,
Johnson K,
Lutz C,
Rockwood S,
Sasner M
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.576
Subject(s) - cancer research , immunology , inflammation , biology , medicine
The Jackson Laboratory Repository serves as a centralized facility to import, develop, preserve, and distribute mouse models to the scientific community. Approximately 300 strains are added annually to the largest collection of characterized mouse strains available. Mouse models of inflammation include: a spontaneous mutation in Sharpin (chronic proliferative dermatitis), a variant of Il4ra developing a heightened IgE response and amplified allergic airway inflammation, and Stat5a and Stat5b signal transducer and transcription activator targeted mutations (BALB/cJ background). Recent additions include a targeted mutation of Il8rb with impaired wound healing/angiogenesis/tumor growth, a Trp53 targeted mutation abolishing apoptosis in thymocytes and causing a range of malignancies, a knock‐in of Trp53 with phosphorylation site mutations which stops p53‐dependent apoptosis, and a floxed allele of Sfpi1 (PU.1) for studies of T cell lymphoma, acute myelogenous leukemia (AML), and a variety of other cancers. The Repository maintains a searchable on‐line resource ( www.jaxmice.jax.org/query ). Researchers can submit strains to the Repository at www.jax.org/grc . The Jackson Laboratory Repository is supported by the NCRR (RR09781, RR11083, RR16049), NIA, The Howard Hughes Medical Institute, The Ellison Medical Foundation and donations from private charitable foundations.