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Induction of T helper 1‐like regulatory are induced by Capsular polysaccharide A (PSA) of Bacteroides fragilis through IFN‐r and Foxp3
Author(s) -
Lee Keun Hwa,
RuizPerez Begonia,
Yun YeoJun,
Tzianabos Arthur O.,
Park ChungGyu,
Kasper Dennis L.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.501
Subject(s) - bacteroides fragilis , il 2 receptor , foxp3 , immune system , t cell , interleukin 21 , antigen presenting cell , biology , cytokine , interleukin 12 , microbiology and biotechnology , antigen presentation , cytotoxic t cell , immunology , chemistry , in vitro , biochemistry , antibiotics
Capsular polysaccharides are common in many bacterial species and have long been considered T cell‐independent antigens that primarily induce humeral immune response. However, polysaccharide A (PSA) of B. fragilis , which possess both a positive charge and a negative charge motif, can activate CD4 + T cells after processing and presentation by antigen‐presenting cells. This CD4 + T cells can modulate surgical fibrosis (T helper 1‐mediated fibrosis) by the release of IL‐10 in vivo , and this proposed T‐cell‐mediated anti‐inflammatory response is reminiscent of the function that has now been attributed to distinct subsets of regulatory T cells, particularly T regulatory 1 (T R 1) cells. Here we have described the protection mechanism against inflammation in response to PSA in vitro (Human CD4 + T cells) and in vivo (mouse model). PSA‐specific induce CD4 + T cells produce IFN‐γ, which is known as a pro‐inflammatory cytokine, after the production of IFN‐γ, Foxp3, which is required for the activation of T R cells in CD4 + T cells, is expressed by IFN‐γ, and then these CD4 + T cells may be convert to inducible regulatory T cells (CD4 + CD25 − CD45RB lo Foxp3 + T cells). These CD4 + T cells release IL‐10, which is regulate immune response, protection conferred in colitis and modulation of surgical fibrosis.